Mystery solved. A protein’s unfolded intermediates can bind to ligands and impact affinity
The native state of a protein is not one single conformation, but an ensemble of…
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MST proves to be an essential tool for SAR study aimed at using apoptosis to fight cancer
Developing and taking a drug to market is a long and expensive path: on average…
Label-free MST takes a deeper look at bacteria’s vulnerable site and reveals potential druggable target
A group from the University of Gothenburg recently published a functional characterization of a bacterial…
In the wild! Characterizing protein variants in native environment uncovers risk for large artery atherosclerotic stroke
Proteins don’t always behave the way they do in their natural environment when studied in…
Why being highly sensitive is a good thing – Measuring RNA-ligand binding interactions using less sample
RNA molecules come in different shapes and sizes and regulate all kinds of biological processes.…
In science we trust!…Wait, do we?
So much of scientific work is irreproducible. Why is that? What can be done to…
Microscale Thermophoresis generated Kd values for Affimer proteins surpassing pitfalls of other technologies
Affimers are a good alternative to antibodies — they’re small engineered binding proteins that possess…
MicroScale Thermophoresis makes it possible to measure binding affinity of Nanobodies under the harshest conditions
Antibodies are widely recognized as the gold standard for biological recognition, but unfortunately these molecules…
ChromoTek uses Prometheus and discovers the extraordinary stability of their GBP:GFP complex
Although traditional IgG antibodies are often used for immunoprecipitation and protein interaction analysis, GFP-binding protein…