The Prometheus NT.48 now allows us to quickly test the stability of proteins in different buffer conditions and even in the presence of detergents. This enables us to also measure membrane proteins in close to native conditions, which is not possible with the conventional DSF method. The unmatched resolution due to the high density of data points are very beneficial for antibody engineering projects since multiple transitions can be identified and determined with high accuracy and reproducibility. We also appreciate that the instrument is very robust and absolutely maintenance-free.
Dr. Thomas Schubert