The nanoDSF instrument from NanoTemper Technologies has become one of the primary techniques to screen for the thermal stability of globular proteins at Novo Nordisk A/S. The instrument and software are intuitive and easy to handle which makes this suitable as a walk-up instrument. The method is very versatile due to fluorescence and aggregation optics, low sample consumption, concentration range and insensitivity towards many buffers and excipients. For globular proteins with tryptophan residues we yield high quality thermal unfolding data which compare with other conventional methods.
Dr. Nikolai Lorenzen
Novo Nordisk A/S