Using MST and nanoDSF we could detect small molecule-protein interactions with high specificity, something that conventional biophysical techniques like SPR and intrinsic tryptophan fluorescence based studies had failed to detect. What gives nanoDSF and MST an edge over other techniques is their rapidity of analysis, ease of use and low material consumption. Also, NanoTemper Technologies’ Application Specialists provide great support, regarding all aspects from assay design, to sample preparation and final data analysis.
Post Doctoral Fellow (Prof. Nagaraja Team)
Dept. of Microbiology and Cell Biology, Indian Institute of Science