Characterizing Protein StabilityPowerful Approaches to Study Protein Denaturation
Measuring protein stability is necessary for numerous applications from understanding the molecular basis for certain diseases to developing more effective drugs. Whether you’re just starting to learn about characterizing a protein’s stability or you’re looking for a refresher, this guide has some helpful tips to answer why it’s important, what technologies are available and how to thoroughly evaluate them before purchasing.
What you’ll learn
Why measuring protein stability is necessary
Understanding proteins stability is key to gaining insights into the function, regulation, and regulatory roles of a molecule. From describing cellular pathways in certain diseases to applications such as screening and developing candidates for new drugs, learn how characterizing a protein’s stability informs your research decisions.
How to characterize protein stability
To measure a protein’s stability, you need to look at how it unfolds. Learn about the two common methods used to cause protein unfolding – thermal and chemical – and what parameters you should be measuring.
Which techniques and technologies are best for you
There are several dedicated techniques and technologies that enable the characterization of protein stability, and they all have different strengths and weaknesses. Learn what they are and discover the right one for your research.
What to think about when evaluating technology
There is more than just the price tag to consider when finding an instrument. With a helpful step-by-step buyer’s checklist, learn practical tips on evaluating your research needs, exploring vendors, and getting your organization on board.