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Merck and NanoTemper Workshop

Support your Tricky Interactions and Protein Characterization Studies with Novel Biophysical Methods

二月 19, 2025

Merck KGaA

Darmstadt, Germany

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Join us to learn about the new biophysical devices of NanoTemper Technologies which is used to study biomolecular interaction and protein stability.

 

Monolith X is a new in-solution affinity measuring device which requires very low sample volume, easy-to-use and maintenance free.

 

For protein characterization please explore Prometheus Panta for simultaneous measurement of protein stability, aggregation propensity, particle size. This device is equipped with 4 different technologies: nanoDSF, Back reflection, DLS, and SLS.

 

Andromeda X helps researchers to find expression conditions that yield the optimal amount of correctly folded protein, regardless of the expression system. It allows users to assess protein binding activity earlier with thermal shift assays and to run assays directly in crude lysates or supernatants from pilot studies or small-scale expressions before deciding to purify.

 

Come see these new tools in the lab and discover how they can help you advance your research. We will introduce you to the technologies, guide you through the software and work with you hands-on using samples.

What can you expect

  • Learn and gain detailed insights into Monolith X, Andromeda X, and Prometheus Panta.

  • Experience these technologies first-hand by testing samples during the hands-on session.

  • Discuss your own projects with experts and discover how scientists in your area have implemented the technologies successfully in their research.

Workshop program and agenda

二月 19, 2025
Register now
Wednesday, 二月 19, 2025
  • 09:30

    Introduction from Merck KGaA
    Dr. Ansgar Wegener & Dr. Nina Grossmann, Merck Healthcare KGaA

  • 09:40

    Introduction from NanoTemper Technologies
    Dr. Gianluca Russo, Account Manager, NanoTemper Technologies

  • 09:50

    Unraveling Protein Stability: A Journey from Expression to Advanced Biophysical Analysis Using Andromeda X and Prometheus Panta
    Dr. Ping Zhang, Field Application Scientist, NanoTemper Technologies

  • 10:25

    From Screening to Validation: Exploring Biomolecular Interactions with Spectral Shift Technology
    Dr. Gianluca Russo, Account Manager, NanoTemper Technologies

  • 11:00

    Coffee Break

  • 11:30

    Utilization of Nano Differential Scanning Fluorimetry as an Efficient Tool for Routine Thermal Stability Assessment of Monoclonal Antibodies and Antibody-Drug Conjugates
    Dr. Jason Tonillo, Lab Head of ADC Analytics, ADCs & Targeted NBE Therapeutics, Merck Healthcare KGaA

  • 12:00

    Characterization of binary & ternary PROTAC complexes in solution using Monolith X
    Dr. Fiona Sorrell, Lab Head, Structural Biology & Biophysics, Discovery Pharmacology, Merck Healthcare KGaA

  • 12:30

    TBD
    Dr. Can Araman, Senior Manager Protein Formulation Laboratory - Liquid Formulation R&D Life Science, Process Solutions, Upstream & Process Materials R&D, Merck Healthcare KGaA

  • 13:00

    Lunch break
    (optional)

  • 14:00

    Measurements of samples for pre-registered attendees
    (optional)

Who should attend?

Anyone working in the field of biological research dealing with proteins and biomolecular interactions.

Register now

二月 19, 2025
Merck KGaA

Darmstadt, Germany