Qualify for a free Tycho and join the 1001 Protein Challenge

Nature survey shows there’s a reproducibility crisis

After Nature published a survey of 1576 researchers, it became clear that the life science research community is facing a reproducibility crisis and, as a result, wasting a lot of money. One finding was: “More than 70% of researchers have tried and failed to reproduce another scientist’s experiments, and more than half have failed to reproduce their own experiments.” A lot of times, researchers can’t reproduce published results because they simply start with a low-quality sample or even the wrong protein.


What can you do about it?

Our research intern Babitta was determined to make sure that she wouldn’t run into this problem throughout her research career. That’s why she launched a protein database that acts as a reference table for researchers in the future. She started populating this database by taking very quick and simple Tycho NT.6 measurements. This measurement data allows researchers to know the quality of the protein in only three minutes and just 10 µL of sample.

And the database is growing! 5 partnering organizations, like ProQinase, a contract research organization for drug discovery in oncology, have already signed on.


Join the 1001 Protein Challenge

Babitta’s vision is that every researcher can start an experiment with a certain protein by first taking a simple Tycho measurement and comparing it to the measurement in the database. By doing this, they’ll know if their protein is, for example, not folded anymore, or if the unfolding profile looks completely different, which enables the researcher to start with a fresh protein instead of learning the hard way after two weeks of unsuccessful experiments. Babitta says, “Every researcher should ensure they’re off to a good start by investing a small amount of time and sample before starting any advanced experiment.”

To show that she’s serious, she picked 1000 proteins as a target for the number of measurements and added an extra one, since any number ending with a 1 brings good luck in India.


How to get a free Tycho

To support Babitta and to show our commitment as well, NanoTemper is distributing 10 Tychos for free for one year to organizations to measure proteins in house and upload them to our Tycho.Cloud so we can add them to the database. We’ve already placed 5 Tychos at partnering organizations, including ProQinase.

Help tackle the reproducibility crisis and join Babitta in building a database for everyone by either sending proteins directly to NanoTemper so Babitta can measure and add them to the database, or getting in touch to discuss whether you qualify for one of the free Tychos available for this project!



Send an email to nt.cloud@nanotempertech.com with the subject “1001 Protein Challenge

About the Author

Julia holds a master’s in physics from Ludwig Maximilian University of Munich and a PhD in physics from the University of Melbourne, both studying the optical properties of nanocrystals. During her 4 years at IBM Research Australia, she gained a strong background in computer science working on machine learning projects such as labelling medical images using neural networks. She has also spent time in India to help Pollinate Energy bring solar lights to slum communities and tutored school classes about nanotechnology and coding. Two years ago, she joined Nanotemper and is currently leading the Data Science Team. In her free time, she will be on the yoga mat or in the mountains climbing, hiking, mountain biking or back country snowboarding.
Julia Baldauf