Compare every Monolith system to find the right one

Monolith Pico

The best choice for studying interactions spanning a broad range of sensitivity. Turn pico mode on to measure very strong interactions, or off for weak ones.

Monolith

Choose this if you want the most flexibility when it comes to labeling strategy. Pick the two fluorescent channels you need the most.

Monolith LabelFree

When you just want to measure interactions by detecting the intrinsic fluorescence of your target protein.

Time it takes to get a K_d

10 minutes or less (standard mode for binding affinity)

Dynamic range

1 pM to mM

1 nM to mM

10 nM to mM

Detected molecule range

10¹–10⁷ Daltons

Minimum sample volume measured

4 μL

Samples per run

Up to 24

Temperature control

20-40 °C +/- 0.5 °C (actively controlled)

Fluorescent channels

1 (pico RED) or
2 (pico RED & LabelFree (UV) or
pico RED & BLUE)

2 (RED & LabelFree (UV),
RED & BLUE, RED & GREEN or
BLUE & GREEN)

1 (LabelFree (UV))

Dimensions

36 cm W x 40 cm H x 58 cm D (71 cm D with drawer open)

Weight

27 kg