Optimize your biologic therapeutics for better clinical outcomes.

Selecting the best biologic for development means sifting through data on hundreds or thousands of candidates and conditions. Prometheus Panta delivers high-resolution, multi-parameter stability characterization so you can eliminate weaker candidates earlier and move forward with confidence.

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Our solutions

Prometheus Panta combines thermal unfolding, particle sizing, and aggregation data to give you a comprehensive stability profile of your biologics.

Prometheus Panta integrates four technologies – nanoDSF, backreflection, DLS, and SLS – in a single instrument, collecting data simultaneously throughout the entire thermal ramp. It’s the only instrument that captures a full DLS profile across the thermal ramp, giving you conformational and colloidal stability information from a single 10 µl sample, without dyes or additives. With Tm precision of ±0.2°C and an unmatched F350/F330 ratio resolution of ±0.008, Prometheus Panta reveals subtle differences between candidates that other instruments miss.

Prometheus Panta supports every stage of your biologics workflow, from early screening to regulatory submission.

Whether you’re narrowing a large candidate library or optimizing a formulation buffer, reliable stability data is what drives better pipeline decisions. Prometheus Panta delivers the multi-parameter characterization you need across the full biologics development journey.

Antibody engineering

Engineer full-length antibodies, scFv, and Fab fragments with higher thermodynamic stability. High-density nanoDSF data reveals subtle differences between variants, so you can advance the more stable candidates.

Developability

Predict whether candidates will succeed throughout the pipeline by identifying unfavorable physical properties early. Characterize conformational stability, aggregation propensity, and self-interaction behavior to eliminate poor candidates before investing further.

Formulation optimization

Identify the buffers and excipients that keep your therapeutic stable during storage. Screen conditions for destabilization and aggregation, find protective excipients, and perform accelerated stability studies, all in a single experimental run.

Downstream process development

Monitor stability attributes through scale-up and manufacturing to catch variability before it becomes a problem. Compare conformational and colloidal stability profiles between batches and incorporate stability data into DoE processes.

IND & BLA submissions

Support regulatory submissions with robust stability data on reconstitution, forced degradation, and photostability studies. Panta provides the thermal stability and particle sizing data needed to establish expiration guidelines and long-term storage conditions.

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One experiment. Multiple insights.
Precise multi-parameter data in a single run.

nanoDSF

Measures the thermal stability of your biologic using its intrinsic fluorescence, delivering Tm precision of ±0.2°C and F350/F330 ratio resolution of ±0.008 — revealing subtle differences between candidates that other instruments miss.

Backreflection

Monitors sample turbidity to detect the formation of large amorphous aggregates (>12.5 nm radius), giving you a clear Tturbidity value to compare candidates and formulation conditions.

Dynamic Light Scattering - DLS

Assesses particle size and polydispersity throughout the entire thermal ramp, providing continuous insight into colloidal stability as temperature increases.

Static Light Scattering - SLS

Monitors smaller aggregates and determines molecular weight, with Tscattering and B22 values that reveal self-association behavior and aggregation propensity at high concentrations.